Zinc protoporphyrin IX, a heme oxygenase-1 inhibitor, demonstrates potent antitumor effects but is unable to potentiate antitumor effects of chemotherapeutics in mice-4
Cisplatin at a dose of 2.5, 5.0 or 7.5 mg/kg administered i.p. [A and B] or with cisplatin (5 mg/kg in a single i.p. injection) and 50 mg/kg of Zn(II)PPIX administered i.p. for 7 consecutive days [C and D]. Graphs show the influence of the treatment on the growth of melanoma in mice. *< 0.05 (two way Student's -test) in comparison with controls.<p><b>Copyright information:</b></p><p>Taken from "Zinc protoporphyrin IX, a heme oxygenase-1 inhibitor, demonstrates potent antitumor effects but is unable to potentiate antitumor effects of chemotherapeutics in mice"</p><p>http://www.biomedcentral.com/1471-2407/8/197</p><p>BMC Cancer 2008;8():197-197.</p><p>Published online 11 Jul 2008</p><p>PMCID:PMC2478682.</p><p></p
