D by BD invasion assay. Increased cell invasion was greatly inhibited by 40 μg/ml heparin. **, < 0.01, compared with U251n-pc cells. #, < 0.01, compared with U251n-hpa group of no heparin treatment. (B) mRNA levels of MMP-2 and MMP-9 showed no significant difference between U251n-pc and U251n-hpa cells. (C) No significant differences were detected in MMP-2 and MMP-9 activity between U251n-hpa cells and U251n-pc cells as measured by zymography assay.<p><b>Copyright information:</b></p><p>Taken from "Increased chemotactic migration and growth in heparanase-overexpressing human U251n glioma cells"</p><p>http://www.jeccr.com/content/27/1/23</p><p>Journal of Experimental & Clinical Cancer Research : CR 2008;27(1):23-23.</p><p>Published online 22 Jul 2008</p><p>PMCID:PMC2499998.</p><p></p
