Here, one of the promoters is likely to be at the 5' end of the gene, while the other promoter can occur anywhere else along the gene length with roughly equal probability (B). A different pattern is observed in genes with two active promoters where one is affected by E2 treatment (either activated or inactivated). In this case we can see that, as before, the upstream active promoter is likely to be located at the 5' end of the gene, but the downstream promoter is strongly biased towards the 3' end of the gene (C).<p><b>Copyright information:</b></p><p>Taken from "Genome-wide analysis of alternative promoters of human genes using a custom promoter tiling array"</p><p>http://www.biomedcentral.com/1471-2164/9/349</p><p>BMC Genomics 2008;9():349-349.</p><p>Published online 25 Jul 2008</p><p>PMCID:PMC2527337.</p><p></p
