<p><b>Copyright information:</b></p><p>Taken from "Effect of circulation on the disposition and ocular tissue distribution of 20 nm nanoparticles after periocular administration"</p><p></p><p>Molecular Vision 2008;14():150-160.</p><p>Published online 29 Jan 2008</p><p>PMCID:PMC2254958.</p><p></p> The profiles were simulated for 20 nm and 200 nm particles for a period of 60 days. The elimination rate of the 20 nm formulation was obtained by curve fitting to the previously published data []. The estimated elimination half-life for 20 nm particles was 5.5 h. The elimination half-life for the 200 nm particles was assumed to be 180 days since they persisted almost completely for at least two months in the periocular space []. All other model parameters used in the model are shown in . The structural model is shown above the simulation. The panels depict profiles of 20 and 200 nm particles with a release rate constant of 0.016 min (), profiles of 20 and 200 nm particles with a release rate constant of 0.0016 min(), profiles of 20 and 200 nm particles with a release rate constant of 0.00016 min (), and profiles of 20 and 200 nm particles with a release rate constant of 0.000016 min (). The insets in each panel are the profiles for the first 24 h of drug release to better show the early differences between the retinal concentrations of celecoxib using 20 and 200 nm particles
