IHC expression patterns of up-regulated genes in <i>p53</i> mutant phenotypes of MS CRCs.

Abstract

<p><b>a</b>, normal colonic epithelium (NCE) demonstrating moderate cytoplasmic (thick arrow) and weak membrane (thin arrow) FUT3 staining (400 µm). <b>b</b>, CRCs exhibiting strong cytoplasmic (thick arrows) and moderate to weak membrane FUT3 staining (thin arrows) (400 µm). <b>c</b>, CRCs with weak cytoplasmic staining (thin arrows) (400 µm). <b>d</b>, NCE demonstrating weak cytoplasmic TRIM29 staining with a focal punctuate pattern (thin arrows) (400 µm). <b>e</b>, CRCs exhibiting moderate to strong cytoplasmic TRIM29 staining with a punctate pattern on the luminal aspect (thin arrows) (600 µm). <b>f</b>, CRCs with weak cytoplasmic TRIM29 staining (thin arrows) (400 µm). <b>g</b>, NCE demonstrating weak cytoplasmic to complete lack of IQGAP3 staining. [Note: Lymphocytes in the stroma show moderate cytoplasmic staining (thin arrows); the adjacent tumor demonstrates moderate cytoplasmic and nuclear immunostaining (thick arrows) (400 µm)]. <b>h</b>, CRCs exhibiting strong cytoplasmic IQGAP3 staining (thick arrows) (400 µm). <b>i</b>, CRCs with lack of staining for IQGAP3 (thick arrows) (400 µm). <b>j</b>, NCE demonstrating moderate cytoplasmic staining of SLC6A8 staining (thin arrows) (600 µm). <b>k</b>, CRCs exhibiting strong cytoplasmic SLC6A8 staining with luminal accentuation (thick arrows) (600 µm). <b>l</b>, CRCs negative for SLC6A8 staining (thick arrows) (600 µm).</p