Enantioselective Syntheses
of the Alkaloids <i>cis</i>-195A (Pumiliotoxin C) and <i>trans</i>-195A
Based on Multiple Applications of Asymmetric Catalysis
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Abstract
Short enantio- and diastereoselective syntheses of the
decahydroquinoline
alkaloids <i>cis</i>- (pumiliotoxin C) and <i>trans</i>-<b>195A</b> are presented. Key steps are an enantioselective
iridium-catalyzed allylic amination, a Suzuki–Miyaura coupling,
a catalyst-controlled copper-catalyzed 1,4-addition, and a reductive
amination