Credneramides A and B:
Neuromodulatory Phenethylamine
and Isopentylamine Derivatives of a Vinyl Chloride-Containing Fatty
Acid from cf. <i>Trichodesmium</i> sp. nov.
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Abstract
Credneramides A (<b>1</b>) and B (<b>2</b>), two vinyl
chloride-containing metabolites, were isolated from a Papua New Guinea
collection of cf. <i>Trichodesmium</i> sp. nov. and expand
a recently described class of vinyl chloride-containing natural products.
The precursor fatty acid, credneric acid (<b>3</b>), was isolated
from both the aqueous and organic fractions of the parent fraction
as well as from another geographically and phylogenetically distinct
cyanobacterial collection (Panama). Credneramides A and B inhibited
spontaneous calcium oscillations in murine cerebrocortical neurons
at low micromolar concentrations (<b>1</b>, IC<sub>50</sub> 4.0
μM; <b>2</b>, IC<sub>50</sub> 3.8 μM)