<p>(A) Expression of <i>Bdnf</i> transcripts from different promoters (<i>Bdnf I</i>, <i>IV</i> and <i>V</i>) and the coding region (<i>Bdnf B</i>) in the cortex are represented as a percent of WT expression levels. With the exception of a slight decrease in <i>Bdnf</i> V, <i>Hdac3</i> reduction did not affect <i>Bdnf</i> expression. (B) Expression levels of genes specifically altered in the cerebellum of R6/2 mice are represented as a percent of WT expression. No significant difference was induced by <i>Hdac3</i> genetic reduction. (C) Expression levels of genes specifically altered in the striatum of R6/2 mice are represented as a percent of WT expression. A significant decrease in the expression of <i>Cnr1</i> in non-transgenic animals was observed as well as a slightly significant increase in <i>Cnr1</i> expression in R6/2 striata. Expression of the R6/2 transgene in Dbl brains is represented as a percent of that in R6/2 brains for cortex (D), cerebellum (E) and striatum (F). <i>Hdac3</i> reduction did not induce a significant change in transgene expression. Error bars correspond to S.E.M. (n = 8) *p<0.05. The same color code (blue = WT; red = Hdac3; green = R6/2 and purple = Dbl) was used for all the graphs. <i>Bdnf I, IV V</i>, brain derived neurotrophic factor promoter I, IV, V; <i>Bdnf B</i>, brain derived neurotrophic factor coding exon B; <i>Igfbp5</i>, insulin-like growth factor binding protein 5; <i>Kcnk2</i>, potassium channel subfamily K, member 2; <i>Nr4a2</i>, nuclear receptor subfamily 4, group A, member 2; <i>Pcp4</i>, Purkinje cell protein 4; <i>Uchl1</i>, ubiquitin C-terminal hydrolase L1; <i>Cnr1</i>, cannabinoid receptor 1; <i>Darpp32</i>, dopamine and cAMP regulated neuronal phosphoprotein; <i>Drd2</i>, dopamine D2 receptor; <i>Penk1</i>, proenkephalin.</p
