Histidine-Catalyzed Asymmetric
Aldol Addition of Enolizable Aldehydes: Insights into its Mechanism
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Abstract
Extensive studies of asymmetric cross-aldol addition
between enolizable aldehydes are described and provide a deeper insight
into histidine-catalyzed aldol additions. In particular, aspects of
enantio- as well as diastereoselectivity of these reactions are discussed.
Rules and predictions of configurative outcome are explained by using
different transition-state models. These discussions are confirmed
by extensive computations