Copper-Catalyzed Aerobic [3+2]-Annulation of <i>N</i>-Alkenyl Amidines

Abstract

A method for the synthesis of bi- and tricyclic amidines has been developed through copper-catalyzed aerobic [3+2]-annulation reaction of <i>N</i>-alkenyl amidines. These cyclic amidines could be converted into mono-benzyl-protected vicinal diamines by the reduction with aluminum hydride