Tumor phenotype in Mock/MYC, FLIP<sub>L</sub>/MYC, BCL-X<sub>L</sub>/MYC and BCL-2/MYC recipient mice.

Abstract

<p>Summary of flow cytometry analysis of spleen cells from moribund mice transplanted with HSC expressing (A) Mock-GFP/MYC-YFP into DBA/2 mice, (B) FLIP<sub>L</sub>-GFP/MYC-YFP into DBA/2 mice, (C) BCL-X<sub>L</sub>-GFP/MYC-YFP into DBA2 mice, (D) BCL-X<sub>L</sub>-GFP/MYC-YFP into BALB/c mice and (E) BCL-2-GFP/MYC-YFP into BALB/c mice. Left panel specify tumors expressing MYC-YFP only and right panel specify cells expressing MYC-YFP together with either Mock-GFP (A), FLIP<sub>L</sub>-GFP (B), BCL-X<sub>L</sub>-GFP (C and D) or BCL-2-GFP (E). Filled box indicate tumor phenotype. M indicates tumors of myeloid lineage, DP indicate CD4<sup>+</sup>CD8<sup>+</sup> lymphoid tumors, 4 indicate CD4<sup>+</sup> lymphoid tumors and 8 indicate CD8<sup>+</sup> lymphoid tumors. Numbers correspond to identity of individual animal.</p

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