Synthesis of Azaphilone-Based
Chemical Libraries
- Publication date
- Publisher
Abstract
The synthesis of azaphilone scaffolds that have been
further diversified
by cross coupling acylation and amine addition is reported. Methodology
development also led to novel modifications including C5 acetoxylation
and condensations producing isoquinolin-6(7H) structures. Overall,
the library synthesis afforded three azaphilone sublibraries, including
vinylogous pyridones which project diversity elements in four sectors
of the azaphilone core