Full Surface Embedding
of Gold Clusters on Silicon Nanowires for Efficient Capture and Photothermal
Therapy of Circulating Tumor Cells
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Abstract
We report on rapid thermal chemical vapor deposition
growth of silicon nanowires (Si NWs) that contain a high density of
gold nanoclusters (Au NCs) with a uniform coverage over the entire
length of the nanowire sidewalls. The Au NC-coated Si NWs with an
antibody-coated surface obtain the unique capability to capture breast
cancer cells at twice the highest efficiency currently achievable
(∼88% at 40 min cell incubation time) from a nanostructured
substrate. We also found that irradiation of breast cancer cells captured
on Au NC-coated Si NWs with a near-infrared light resulted in a high
mortality rate of these cancer cells, raising a fine prospect for
simultaneous capture and plasmonic photothermal therapy for circulating
tumor cells