<p>Hypothetic hippo pathway components in mammals are shown in various colors, with pointed and blunt arrowheads indicating activating and inhibitory interactions, respectively. The pathway regulates transcriptions of several genes, among others that of <i>Birc5</i>. Based on <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0033573#pone.0033573-Zhao1" target="_blank">[36]</a>, <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0033573#pone.0033573-Heallen1" target="_blank">[37]</a>, <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0033573#pone.0033573-Dong1" target="_blank">[38]</a>. According to this pathway lower level of <i>FRMD6</i> might be associated with higher level of <i>Birc5</i>, as was found in the lung of the animal model of asthma.</p
