Model of high- and low-connectivity interactors identified in this screen that either modify the Hsp90/Cdc37 complex or are affected by it.

Abstract

<p>The high connectivity interactors (red) modulate gene expression, protein levels, or phosphorylation of Hsp90 and Cdc37, while the chaperone complex regulates gene expression, protein levels or activation of low-connectivity interactors (blue).</p