Enantioselective Total Synthesis of (+)-Amabiline

Abstract

The first total synthesis of (+)-amabiline, an unsaturated pyrrolizidine alkaloid from <i>Cynoglossum amabile</i>, is reported. This convergent, enantioselective synthesis proceeds in 15 steps (10-step longest linear sequence) in 6.2% overall yield and features novel methodology to construct the unsaturated pyrrolizidine or (−)-supinidine core