Selective Excitation 1D-NMR
Experiments for the Assignment
of the Absolute Configuration of Secondary Alcohols
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Abstract
Routine selective excitation experiments, easy to set
up on modern
NMR spectrometers, allow for the determination of the absolute configuration
of chiral secondary alcohols by double derivatization directly in
the NMR tube. As a general method, TOCSY1D with selective excitation
of the α proton in the MPA esters and with a short mixing time
reveals only the nearby protons in the coupling network. Typically,
the analysis takes less than 30 min. A longer mixing time, selective
excitation of other signals, or NOESY1D experiments can be used for
measuring Δδ<i>RS</i> of other protons