Hyaladione, an <i>S</i>-Methyl Cyclohexadiene-dione
from <i>Hyalangium minutum</i>
- Publication date
- Publisher
Abstract
A bioassay-guided fractionation of the crude methanol
extract of
the myxobacterium <i>Hyalangium minutum</i>, strain NOCB-2<sup>T</sup> (DSM 14724<sup>T</sup>), led to the isolation of hyaladione
(<b>1</b>), a
novel <i>S</i>-methyl cyclohexadiene-dione. The structure
of <b>1</b> was established by HRESIMS, NMR, and IR spectroscopy
as well as X-ray crystallography. Compound <b>1</b> was active
against growing mammalian cell lines, with IC<sub>50</sub> values
ranging from 1.23 to 3.93 μM, in addition to a broad spectrum
of antibacterial and antifungal activities, including inhibition of
pathogenic methicillin-resistant <i>Staphylococcus aureus</i> and <i>Pseudomonas aeruginosa</i> with an MIC of 0.83
and 8.5 μg mL<sup>–1</sup>, respectively
