Access to Spirocyclic Oxindoles via N-Heterocyclic Carbene-Catalyzed Reactions of Enals and Oxindole-Derived α,β-Unsaturated Imines

Abstract

A diastereoselective access to <b>β</b>-lactam fused spirocyclic oxindoles and related compounds bearing all carbon spiro centers is described. This N-heterocyclic carbene-catalyzed process employed challenging <b>β,β</b>-disubstituted <b>α,β</b>-unsaturated imines to react with enals