<i>N</i>′-Nitro-2-hydrocarbylidenehydrazinecarboximidamides:
Design, Synthesis, Crystal Structure, Insecticidal Activity, and Structure–Activity
Relationships
- Publication date
- Publisher
Abstract
A novel series of acyclic imine-substituted nitenpyram
analogues
were designed and synthesized from nitroaminoguanidine, and their
structures were confirmed using X-ray diffraction crystallography.
Preliminary bioassays showed that the target molecules exhibited good
activities against aphids in laboratory (<i>Myzus persicae</i> Sulzer) and field trials (<i>M. persicae</i> Sulzer and <i>Brevicoryne brassicae</i> Linnaeus). Comparative molecular field
analysis and comparative molecular similarity indices analysis were
employed to develop a three-dimensional quantitative structure–activity
relationship model that describes the insecticidal activity of 21
neonicotinoid derivatives. Simple synthesis, low cost, and good insecticidal
activity have made this series of compounds become very promising
candidates for future commercial pesticides