Rotamers or Diastereomers?
An Overlooked NMR Solution
- Publication date
- Publisher
Abstract
The existence of rotamers in a solution of analyte complicates <sup>1</sup>H NMR analysis, especially when the presence of diastereomers
is also possible. Organic chemists have often responded to this problem
by conducting variable-temperature (VT) NMR experiments, changing
NMR solvents, or adding complexing agents. Here, with specific examples,
we illustrate the use of simple yet widely overlooked chemical-exchange
NMR experiments which allow the nonintrusive rapid distinguishment
of rapidly equilibrating small molecules such as rotamers from nonequilibrating
diastereomers