Optical Resolution of Aromatic Alcohols Using Silica Nanoparticles Grafted with Helicene

Abstract

Optically active silica nanoparticles, with a 70-nm diameter, grafted with (<i>P</i>)-1,12-dimethyl-8-methoxycarbonylbenzo[<i>c</i>]phenanthrene-5-carboxyamide were synthesized, and their use in the kinetic resolution of aromatic alcohols was examined. Up to 61% ee for (<i>S</i>)-2,2-dimethyl-1-phenyl-1-propanol was obtained by a preferential precipitation of aggregates formed with (<i>P</i>)-nanoparticles