Highly Selective Mild
Stepwise Allylation of <i>N</i>-Methoxybenzamides with Allenes
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Abstract
An efficient Rh(III)-catalyzed stepwise ortho allylation
of <i>N</i>-methoxybenzamides <b>1</b> with polysubstituted
allenes is reported. This C–H functionalization involving allenes
is conducted under very mild conditions (−20 °C or room
temperature) and compatible with ambient air and moisture, and it
can be applied to terminal or internal allenes with different synthetically
attractive functional groups. Highly efficient axial chirality transfer
has been realized, yielding optically active lactones