<i>In vivo</i> angiogenesis by modified-matrigel implantation assay is enhanced in BAMBI<sup>−/−</sup> mice in comparison to their BAMBI<sup>+/+</sup> littermates.
<p><b>A. </b><i>In vivo</i> angiogenesis was evaluated under basal conditions and in the presence of VEGF and FGF in the implants in BAMBI<sup>+/+</sup> and BAMBI<b><sup>−</sup></b><sup>/<b>−</b></sup> mice. In-growth of endothelial cells was evaluated after 12 days by isolectin B4 fluorescence determination. Results are means ± SEM from 4 animals per group. # <i>P</i><0.05 <i>vs</i>. respective basal values; * <i>P</i><0.05 BAMBI<b><sup>−</sup></b><sup>/<b>−</b></sup><i>vs</i>. BAMBI<sup>+/+</sup>. <b>B.</b> Comparable experiments except that TGFβ ± LY364947 or LY364947 alone were added to the matrigel implants. Results are means ± SEM from 5 mice per group. * <i>P</i><0.05 comparing respective basal <i>vs.</i> growth factor stimulated values and # <i>P</i><0.05 for group comparison of BAMBI<sup>+/+</sup> and BAMBI<b><sup>−</sup></b><sup>/<b>−</b></sup> mice in the same condition.</p
