<p>(A) Expression of exogenous RAP80 in TOV-21G cells. (B) Cells loss of RAP80 are hypersensitive to IR. TOV-21G and TOV-21G-RAP80 cells were treated with indicated dose of IR. Survival cell colonies were calculated. (C) Comet assays show that loss of RAP80 impairs DNA damage repair. Representative images of neutral comet assays are shown. Bar: 10 µm. (D) The moment of comet tail were quantitatively measured. *<i>P</i> values<0.01; NS means no statistical significance. (E) Exogenous RAP80 restores the IRIF of the BRCA1-A complex in TOV-21G cells. Bar: 10 µm. (F) Foci positive cells are summarized. Data are from three independent experiments and error bars stand for standard deviation. *<i>P</i> values<0.01.</p
