<p>50,000 cells from a stably transfected B16f1 melanoma cell line (Clone 11) were injected in the backs of <i>cd36</i> null (A) or <i>hrgp</i> null (B) mice. C57BL/6 mice were used as controls. Tumor volumes were assessed at timed points as in <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0040033#pone-0040033-g001" target="_blank">Figures 1</a> and <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0040033#pone-0040033-g003" target="_blank">3</a>. *P<0.05; **P = 0.08; ***P = 0.06. LL2 cells stabily transfected with nontargeted (NT) or TSP targeted constructs, K1 and K2, constructs were similarly injected subcutaneously onto the backs of wildtype (WT) and cd36 null mice (Null). (<b>C</b>) WT-NT tumors grew smaller than WT-K1 and WT-K2 tumors, with statistically significant differences seen at days 7 and 15 for both NT vs K1 and NT vs K2. (<b>D</b>) No differences were observed between NT, K1 and K1 in cd36 null mice.</p
