Total Synthesis of (−)-FR901483
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Abstract
A total synthesis of the immunosuppressive alkaloid (−)-FR901483 (<b>1</b>) has been described. The intriguingly azatricyclic structure of <b>1</b> was constructed by the semipinacol-type rearrangement and intramolecular Schmidt reaction of an azido cyclohexanone derivative. This strategy provides a distinctive and competitive approach to the natural product <b>1</b>