Copper-Catalyzed Aerobic
Aliphatic C–H Oxygenation
Directed by an Amidine Moiety
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Abstract
A method for the oxygenation of tertiary C–H bonds
of <i>N</i>-alkylamidines and <i>N</i>-(2-alkylaryl)amidines
is described that utilizes the CuBr·SMe<sub>2</sub>/2,2′-bipyridine
catalytic system under an O<sub>2</sub> atmosphere and provides dihydrooxazoles
and 4<i>H</i>-1,3-benzoxazines. The oxygen atom is incorporated
from atmospheric molecular oxygen during the present process