Palladium-Catalyzed, Asymmetric
Mizoroki–Heck
Reaction of Benzylic Electrophiles Using Phosphoramidites as Chiral
Ligands
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Abstract
We report herein the first examples of asymmetric Mizoroki–Heck
reactions using benzyl electrophiles. A new phosphoramidite was identified
to be an effective chiral ligand in the palladium–catalyzed
reaction. The reaction is compatible with polar functional groups
and can be readily scaled up. Several cyclic olefins worked well as
olefin components. Thirty-one examples are included