Busseihydroquinones A–D
from the Roots of <i>Pentas bussei</i>
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Abstract
Four new naphthohydroquinones, named busseihydroquinones
A–D
(<b>1</b>–<b>4</b>), along with a known homoprenylated
dihydronaphthoquinone (<b>5</b>), were isolated from the CH<sub>2</sub>Cl<sub>2</sub>/MeOH (1:1) extract of the roots of <i>Pentas bussei</i>. Although the genus <i>Pentas</i> is frequently used by traditional healers for the treatment of malaria,
only marginal activities against the chloroquine-sensitive (D6) and
the chloroquine-resistant (W2) strains of <i>Plasmodium falciparum</i> were observed for the crude root extract and the isolated constituents
of this plant