Glycan-Targeted Virus-like
Nanoparticles for Photodynamic
Therapy
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Abstract
Virus-like particles (VLPs) have proven to be versatile
platforms
for chemical and genetic functionalization for a variety of purposes
in biomedicine, catalysis, and materials science. We describe here
the simultaneous modification of the bacteriophage Qβ VLP with
a metalloporphyrin derivative for photodynamic therapy and a glycan
ligand for specific targeting of cells bearing the CD22 receptor.
This application benefits from the presence of the targeting function
and the delivery of a high local concentration of singlet oxygen-generating
payload