Transition-Metal-Free
Superbase-Promoted Stereoselective α‑Vinylation of Ketones
with Arylacetylenes: A General Strategy for Synthesis of β,γ-Unsaturated
Ketones
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Abstract
A wide variety of β,γ-unsaturated ketones
of <i>E</i> configuration have been obtained in good to
excellent yields via KO<sup><i>t</i></sup>Bu/DMSO promoted
α-vinylation of aliphatic, cycloaliphatic, and alkyl aromatic
(heteroaromatic) ketones with diverse arylacetylenes