Building Multivalent Iminosugar-Based
Ligands on Calixarene
Cores via Nitrone Cycloadditions
- Publication date
- Publisher
Abstract
A novel and challenging approach for the construction
of multivalent
iminosugar architectures directly on calixarene scaffolds is presented,
which exploits multiple cycloaddition reactions of a carbohydrate-derived
nitrone on diversely functionalized calix[4]arenes. Regardless of
the 4-fold reiteration on a single calixarene, the reactions take
place with high regio- and stereoselectivity, demonstrating this method
as an appealing one for the synthesis of calixarene-based neoglycoconjugates