Facile and Rapid Access
to Glyconanocapsules by CuAAC
Interfacial Polyaddition in Miniemulsion Conditions
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Abstract
Glyconanocapsules with a biocompatible oily core have
been successfully
prepared by copper(I)-catalyzed azide–alkyne cycloaddition
(CuAAC) interfacial step growth polymerization between 6,6′-diazido-6,6′-dideoxysucrose
and bis(propargyloxy)butane in oil-in-water miniemulsion conditions.
Optimization of the interfacial polymerization process in dispersed
medium afforded the rapid and reproducible preparation of stable monodispersed
glyconanocapsules having a diameter around 200 nm