The <i>B. anthracis</i> chromosome, Leading and Lagging strand gene score distributions, frequency distributions and median gene expression scores for Sense and Antisense expression by leading and lagging strands.

Abstract

<p>(A) Basic outline of the ∼5.2 Mb chromosome of <i>B. anthracis</i>, showing approximate origin and terminus of replication, and the division scheme of genes on leading and lagging strands. Note that red is the plus strand and green is the minus strand, but “leading” and “lagging” directionality switches at the terminus, with “leading” strand genes going in the same 5′-3′ direction of replication, and “lagging” going in opposite direction. (B-C) Frequency distributions of percentage of genes per leading and lagging strands for sense (B) and antisense (C) transcripts in Control sample. (0* means score of 0.00). (D-E) Median gene expression and interquartile range per quadrant divisions outlined in (A) for sense (D) and antisense (E) gene expression.</p

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