Size and Compositional
Effects on Contrast
Efficiency of Functionalized Superparamagnetic Nanoparticles at Ultralow
and Ultrahigh Magnetic Fields
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Abstract
Magnetic resonance imaging (MRI) systems at ultralow
and ultrahigh
field have been developed for biomedical imaging. We synthesized and
functionalized superparamagnetic (SPM) nanoparticles (NPs) and studied
the spin–lattice (<i>T</i><sub>1</sub>) and spin–spin
(<i>T</i><sub>2</sub>) relaxation time of protons in water
surrounding these NPs at ultralow and at ultrahigh magnetic fields.
In these fields, size and compositional effects of SPM NPs were observed
contributing to the spin–lattice (<i>r</i><sub>1</sub>) and spin–spin (<i>r</i><sub>2</sub>) relaxivities
as well as <i>r</i><sub>2</sub>/<i>r</i><sub>1</sub> ratios. These results reveal the relationship between magnetic characteristics
of SPM NPs and relaxation behavior of water proton at ultralow or
ultrahigh field