Ultrastructural analysis of <i>Ra^op</i> mice.

Abstract

<p>Frontal sections of wild-type (A, C, G) and <i>Ra^op</i> mice (B, D, E, F, H) at E12.5. Epithelium consisted of two or three epithelial cell layers in unaffected regions of <i>Ra^op</i> mice (B). (C) Cytoplasmic plaques were seen as single plaque structures in wild-type (arrowheads). Cytoplasmic plaques were seen as single plaques in unaffected regions of <i>Ra^op</i> mice (D). (E, F, H) Detached epithelium of <i>Ra^op</i> mice. (F) High magnification images taken from boxed regions in panel E. Lamina densa and lamina lucida were retained on the mesenchymal side (arrowheads in F). (H) High magnification of region indicated by arrowhead in E. Cytoplasmic plaque were also seen and retained at basement membranes of affected region of <i>Ra^op</i> mice (arrowheads in H).</p