Copper-Catalyzed Desymmetric
Intramolecular Ullmann
C–N Coupling: An Enantioselective Preparation of Indolines
- Publication date
- Publisher
Abstract
The first highly enantioselective copper-catalyzed intramolecular
Ullmann C–N coupling reaction has been developed. The asymmetric
desymmetrization of 1,3-bis(2-iodoaryl)propan-2-amines catalyzed by
CuI/(R)-BINOL-derived ligands led to the enantioselective formation
of indolines in high yields and excellent enantiomeric excesses. This
method was also applied to the formation of 1,2,3,4-tetrahydroquinolines
in high yields and excellent enantioselectivity