Asymmetric Michael Addition of Ketones to Alkylidene Malonates and Allylidene Malonates via Enamine–Metal Lewis Acid Bifunctional Catalysis

Abstract

Novel enamine–metal Lewis acid bifunctional catalysts were successfully applied to the asymmetric Michael addition of ketones to alkylidene malonates, offering excellent stereoselectivity (up to >99% <i>ee</i> and >99:1 <i>dr</i>). The asymmetric Michael addition of ketones to allylidene malonates was also achieved