Rescue effects of exogenous recombinant CD14 in THP-1 cells incubated with HCMV and treated with IL-6 antisense.

Abstract

<p>TIRAP (A), TRAF6 (C), and IL-8 (D) levels at 6 hours were up-regulated by the addition of 20 ug/ml CD14. Rescue of IFN-β (F) levels at 6 hours was also seen. However, rescued cells showed no change in TRAM (B) and TRIF (E) levels. (means±S.D. n = 4) (*<i>p</i><0.05, **p<0.01 by student T-test compared with control at 6 hours). ELISA revealed a dramatic increase in IL-8 (G) and IFN-β (H) production. Elisa data are means of experiments performed in triplicate.</p