Rethinking Data Collection
and Signal Processing.
1. Real-Time Oversampling Filter for Chemical Measurements
- Publication date
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Abstract
Minimizing noise in chemical measurements is critical
to achieve
low limits of detection and accurate measurements. We describe a real-time
oversampling filter that offers a method to reduce stochastic noise
in a time-dependent chemical measurement. The power of this technique
is demonstrated in its application to the separation of dopamine and
serotonin by micellar electrokinetic chromatography with amperometric
detection. Signal-to-noise ratios were increased by almost an order
of magnitude, allowing for limits of detection of 100 and 120 amol,
respectively. Real-time oversampling filters can be implemented using
simple software algorithms and require no change to existing experimental
apparatus. The application is not limited to analytical separations,
and this technique can be used to improve the signal-to-noise ratio
in any experiment where the necessary sampling rate is less than the
maximum sampling rate of the analog-to-digital converter. Theory,
implementation, and the performance of this filter are described.
We propose that this technique should be the default mode of operation
for an analog-to-digital converter