Iridium-Catalyzed Alkylation
of Methylquinolines with Alcohols
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Abstract
Iridium-catalyzed alkylation of methylquinolines at the
methyl substituent was achieved using alcohols as alkylating agents.
The reaction proceeded through a transfer hydrogenation pathway from
the alcohol to the Ir complex, affording an aldehyde and Ir–H
species, followed by base-assisted aldol condensation and hydrogenation.
This method provides an atom-economical and convenient route to alkylquinolines
from easily accessible methylquinolines