Structure–Activity
Relationship of a Broad-Spectrum
Insect Odorant Receptor Agonist
- Publication date
- Publisher
Abstract
Agonism of insect odorant receptor (OR) cation channels
may represent
a new strategy for the manipulation of destructive insect olfactory-driven
behaviors. We have explored the chemical space around VUAA1, the first
in class agonist of the obligate OR co-receptor ion channel (Orco),
and describe novel compound analogues with increased potency across
insect taxa. Functional analyses reveal several of these VUAA1 structural
analogues display significantly greater potency as compared to the
activity of the previously described active compounds in mobility-based
behavioral assays on mosquito larvae