A Luminescent and Biocompatible
PhotoCORM
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Abstract
The water-soluble rhenium(I) complex <i>fac</i>-[Re(bpy)(CO)<sub>3</sub>(thp)]<sup>+</sup> (<b>1</b>) [CF<sub>3</sub>SO<sub>3</sub><sup>–</sup> salt; bpy = 2,2′-bipyridine,
thp
= tris(hydroxymethyl)phosphine] is both strongly luminescent and photoactive
toward carbon monoxide release. It is stable in aerated aqueous media,
is incorporated into cells from the human prostatic carcinoma cell
line PPC-1, and shows no apparent cytotoxicity. Furthermore, the solvated
Re(I) photoproduct of CO release (<b>2</b>) is also luminescent,
a feature that allows one to track the transformation of <b>1</b> to <b>2</b> inside such cells using confocal fluorescence
microscopy. In this context, <b>1</b> is a very promising candidate
as a photoactivated CO releasing moiety (photoCORM) with potential
therapeutic applications
