Design and Synthesis of
a Novel Series of Bicyclic
Heterocycles As Potent γ-Secretase Modulators
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Abstract
The design and the synthesis of several chemical subclasses
of
imidazole containing γ-secretase modulators (GSMs) is described.
Conformational restriction of pyridone <b>4</b> into bicyclic
pyridone isosteres has led to compounds with high in vitro and in
vivo potency. This has resulted in the identification of benzimidazole <b>44a</b> as a GSM with low nanomolar potency in vitro. In mouse,
rat, and dog, this compound displayed the typical γ-secretase
modulatory profile by lowering Aβ42 and Aβ40 levels combined
with an especially pronounced increase in Aβ38 and Aβ37
levels while leaving the total levels of amyloid peptides unchanged
