Total Synthesis of Chlorocyclinone A, a PPAR‑γ Antagonist

Abstract

The first total synthesis of chlorocyclinone A (<b>1</b>) is regioselectively completed in 28 steps. The key steps are Pd-catalyzed methoxycarbonylation, unprecedented Hauser annulation, Krohn photo-oxidation, and regioselective <i>gem</i>-dichlorination