Analogues of the Epoxy
Resin Monomer Diglycidyl Ether
of Bisphenol F: Effects on Contact Allergenic Potency and Cytotoxicity
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Abstract
Diglycidyl ethers of bisphenol A (DGEBA) and bisphenol
F (DGEBF)
are widely used as components in epoxy resin thermosetting products.
They are known to cause occupational and nonoccupational allergic
contact dermatitis. The aim of this study is to investigate analogues
of DGEBF with regard to contact allergy and cytotoxicity. A comprehensive
knowledge of the structural features that contribute to the allergenic
and cytotoxic effects of DGEBF will guide the development of future
novel epoxy resin systems with reduced health hazards for those coming
into contact with them. It was found that the allergenic effects of
DGEBF were dependent on its terminal epoxide groups. In contrast,
it was found that the cytotoxicity in monolayer cell culture was dependent
not only on the presence of epoxide groups but also on other structural
features