Orthogonal Modification
of Norbornene-Functional Degradable
Polymers
- Publication date
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Abstract
Well-defined norbornene-functional poly(carbonate)s were
prepared
by ring-opening polymerization and utilized as multireactive polymeric
scaffolds in a range of postpolymerization modifications. The norbornene-functional
handles were shown to undergo facile reaction with azides via a 1,3-dipolar
cycloaddition, tetrazines in the inverse electron demand Diels–Alder
reaction and thiols via radical thiol-ene coupling. Furthermore, the
above-mentioned chemistries were demonstrated in a sequential one-pot,
three-step modification reaction illustrating the potential of these
polymers as scaffolds to access multifunctionalized materials in an
undemanding manner