Structure alignment of <i>T. brucei</i> C51 model (TbC51m) with a distant structure homolog, human Cathepsin F (CatF).

Abstract

<p>The superposition shows these two proteins have some general, overall structural similarities, but also large differences near the active site. The TbC51 model is colored in light orange, and the human CatF is in light green. While the catalytic Cys-His dyads are closely superimposed (depicted in ball-and-stick), a striking difference is marked by an arrow indicating the predicted steric clash between the CatF vinyl sulfone inhibitor (red) and the helix of TbC51 that partially obstructs the active site.</p