Total Synthesis of Natural <i>p</i>‑Quinol Cochinchinenone

Abstract

Cochinchinenone has been synthesized in only five steps and four pots and in 58% overall yield from commercially available 2,3-dimethoxy-4-hydroxy-benzaldehyde and OPMB-protected <i>p</i>-hydroxy acetophenone, the key step being the oxone-mediated oxidative dearomatization of the corresponding ketone-containing <i>p</i>-substituted phenol